Table 1.
Main characteristics of children enrolled.
| Patients Characteristics | Uninfected n = 3086 | Latent TB 1 n = 594 | Active TB n = 554 | All n = 4234 |
|---|---|---|---|---|
| Sex | ||||
| Male | 1687/308 (54.7%) | 329/592 (55.6%) | 256/552 (46.4%) | 2272/4227 (53.7%) |
| Female | 1396/3083 (45.3%) | 263/592 (44.4%) | 296/552 (53.6%) | 1955/4227 (46.3%) |
| Age (months)—Median (IQRs) 2 | 68 (34–114) | 110 (65–173) | 59 (20–129) | 72 (35–124) |
| Age distribution | ||||
| ≤1 year | 248/3072 (8.1%) | 13/594 (2.2%) | 83/554 (15%) | 344/4219 (8.2%) |
| 1–4 years | 841/3072 (27.4%) | 90/594 (15.2%) | 167/554 (30.2%) | 1098/4219 (26%) |
| 4–13 years | 574/3072 (51.2%) | 301/594 (50.7%) | 216/554 (39.1%) | 2091/4219 (49.6%) |
| ≥13 years | 409/3072 (13.3%) | 190/594 (32%) | 87/554 (15.7%) | 686/4219 (16.3%) |
| Status | ||||
| Dead | 0 | 0 | 2/554 (0.4%) | 2/4234 (0.1%) |
| Lost to follow-up | 42/3086 (1.4%) | 45/594 (7.6%) | 47/554 (8.5%) | 134/4234 (3.2%) |
| Transferred to another center | 0 | 0 | 7/554 (1.3%) | 7/4234 (0.2%) |
| TB resolution | 0 | 549/594 (92.4%) | 498/554 (89.9%) | 4091/4234 (96.6%) |
| Reason for investigation | ||||
| Adoption/immigrant screening | 1949/3086 (63.2%) | 359/594 (60.4%) | 31/553 (5.6%) | 2339/4233 (55.3%) |
| Contact with suspected/confirmed source case | 976/3086 (31.6%) | 222/594 (37.4%) | 294/553 (53.2%) | 1492/4233 (35.2%) |
| Symptomatic | 161/3086 (5.2%) | 13/594 (2.2%) | 227/553 (41%) | 401/4233 (9.5%) |
| Screening for use of biologic drugs | 0 | 0 | 1/553 (0.2%) | 1/4233 (0.1%) |
| Country of origin | ||||
| Asia | 751/3086 (24.4%) | 119/594 (20%) | 77/554 (13.7%) | 945/4234 (22.4%) |
| South-central America | 493/3086 (16%) | 71/594 (12%) | 53/554 (9.6%) | 617/4234 (14.6%) |
| East Europe | 590/3086 (19.1%) | 175/594 (29.5%) | 138/554 (24.9%) | 903/4234 (21.3%) |
| North America | 1/3086 (0.1%) | 0/594 | 0 | 1/4234 (0.1%) |
| North Africa | 217/3086 (7%) | 64/594 (10.8%) | 74/554 (13.4%) | 355/4234 (8.4%) |
| Sub-saharian Africa | 322/3086 (10.4%) | 88/594 (14.8%) | 51/554 (9.2%) | 461/4234 (10.9%) |
| Italy | 692/3086 (22.4%) | 70/594 (11.8%) | 152/554 (27.4%) | 914/4234 (21.6%) |
| Unknown | 20/3086 (0.6%) | 7/594 (1.2%) | 9/554 (1.6%) | 36/4234 (0.9%) |
| Source case | ||||
| Unknown | 2584/3086 (83.7%) | 480/594 (80.8%) | 321/554 (57.9%) | 3385/4234 (79.9%) |
| Household | 150/3086 (4.8%) | 70/594 (11.7%) | 138/554 (24.9%) | 358/4234 (8.4%) |
| Family member not household | 111/3086 (3.5%) | 27/594 (4.5%) | 53/554 (9.5%) | 191/4234 (4.5%) |
| Other not household | 241/3086 (7.8%) | 17/594 (2.8%) | 29/554 (5.2%) | 300/4234 (7%) |
| BCG 3 vaccination status | ||||
| Unknown | 698/3046 (22.9%) | 165/594 (27.8%) | 223/549 (40.6%) | 1086/4189 (25.9%) |
| Negative | 1086/3046 (35.7%) | 137/594 (23.1%) | 264/549 (48.1%) | 1487/4189 (35.5%) |
| Positive | 1262/3046 (41.4%) | 292/594 (49.2%) | 62/549 (11.3%) | 1616/4189 (38.6%) |
| Scar | ||||
| Unknown | 682/2626 (26%) | 179/523 (34.2%) | 240/525 (45.7%) | 1101/3674 (30%) |
| Negative | 1018/2626 (35.7%) | 160/523 (30.6%) | 240/525 (45.7%) | 1418/3674 (38.6%) |
| Positive | 926/2626 (35.3%) | 184/523 (35.2%) | 45/525 (8.6%) | 1155/3674 (31.4%) |
1 TB: Tuberculosis; 2 IQR: Interquartile Range; 3 BCG: Bacillus Calmette–Guerin.