Table 2.
Significantly-enriched top 40 pathways of the target genes of differently-expressed miRNAs in CCl4-induced liver fibrosis (p < 0.05).
| KEGG ID | Pathway | p-Value | KEGG ID | Pathway | p-Value |
|---|---|---|---|---|---|
| mmu01100 | Metabolic pathways | 8.71 × 10−8 | mmu04020 | Calcium signaling pathway | 3.75 × 10−3 |
| mmu04152 | AMPK signaling pathway | 6.75 × 10−6 | mmu00071 | Fatty acid degradation | 4.23 × 10−3 |
| mmu04920 | Adipocytokine signaling pathway | 4.78 × 10−5 | mmu04022 | cGMP-PKG signaling pathway | 4.62 × 10−3 |
| mmu05200 | Pathways in cancer | 1.90 × 10−4 | mmu04915 | Estrogen signaling pathway | 6.78 × 10−3 |
| mmu00514 | Other types of O-glycan biosynthesis | 3.13 × 10−4 | mmu00601 | Glycosphingolipid biosynthesis: lacto and neolacto series | 7.17 × 10−3 |
| mmu00600 | Sphingolipid metabolism | 4.13 × 10−4 | mmu00561 | Glycerolipid metabolism | 7.21 × 10−3 |
| mmu00533 | Glycosaminoglycan biosynthesis: keratan sulfate | 7.12 × 10−4 | mmu04115 | p53 signaling pathway | 9.55 × 10−3 |
| mmu04910 | Insulin signaling pathway | 9.09 × 10−4 | mmu04666 | Fc γ R-mediated phagocytosis | 9.57 × 10−3 |
| mmu00310 | Lysine degradation | 1.04 × 10−3 | mmu04014 | Ras signaling pathway | 1.00 × 10−2 |
| mmu04068 | FoxO signaling pathway | 1.08 × 10−3 | mmu04725 | Cholinergic synapse | 1.01 × 10−2 |
| mmu04974 | Protein digestion and absorption | 1.34 × 10−3 | mmu04340 | Hedgehog signaling pathway | 1.02 × 10−2 |
| mmu04210 | Apoptosis | 1.53 × 10−3 | mmu04668 | TNF signaling pathway | 1.03 × 10−2 |
| mmu00510 | N-Glycan biosynthesis | 1.62 × 10−3 | mmu04660 | T cell receptor signaling pathway | 1.05 × 10−2 |
| mmu04330 | Notch signaling pathway | 1.62 × 10−3 | mmu04150 | mTOR signaling pathway | 1.12 × 10−2 |
| mmu04080 | Neuroactive ligand-receptor interaction | 1.83 × 10−3 | mmu04142 | Lysosome | 1.25 × 10−2 |
| mmu04611 | Platelet activation | 2.06 × 10−3 | mmu04550 | Signaling pathways regulating pluripotency of stem cells | 1.26 × 10−2 |
| mmu00061 | Fatty acid biosynthesis | 2.21 × 10−3 | mmu01212 | Fatty acid metabolism | 1.27 × 10−2 |
| mmu04913 | Ovarian steroidogenesis | 2.56 × 10−3 | mmu05340 | Primary immunodeficiency | 1.28 × 10−2 |
| mmu04360 | Axon guidance | 2.84 × 10−3 | mmu00280 | Valine, leucine and isoleucine degradation | 1.31 × 10−2 |
| mmu04010 | MAPK signaling pathway | 3.34 × 10−3 | mmu00010 | Glycolysis/gluconeogenesis | 1.36 × 10−2 |
MAPK, mitogen-activated protein kinase; PKG, protein kinase G; TNF, tumor necrosis factor; mTOR, mechanistic target of rapamycin.