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Radiation-induced apoptosis is abrogated in p53 deficient mice but not altered in p21 deficient mice. A robust apoptotic response is observed in subgranular zone 8 h after 5 Gy in nestin-Cre mice but no significant response is observed in nestin-Cre:p53Fl/Fl mice (A–E); p21 genotype status does not alter the apoptotic response (F). n = 3 mice per dose per genotype. Apoptotic cells, arrows.
