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Structures of mTORC1 and mTORC2. mTORC1 phosphorylates substrates including S6K, 4E-BP1, and the unc-51-like kinase 1/mammalian autophagy-related gene 13/focal adhesion kinase family-interacting protein of 200 kDa (ULK1/Atg13/FIP200) complex. mTORC2 phosphorylates substrates including serum/glucocorticoid regulated kinase (SGK) 1, Akt, and protein kinase C-α (PKCα).
