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. Author manuscript; available in PMC: 2016 Dec 17.
Published in final edited form as: Cell. 2015 Dec 17;163(7):1566–1568. doi: 10.1016/j.cell.2015.12.010

Figure 1. Nuclear buffering of a transcriptional regulatory heterogeneity.

Figure 1

Basal-like breast epithelia were cultured as 3D spheroids, cryosectioned, and stained for TGFBR3 by RNA FISH as in Wang et al. (2014). Nuclear (solid) and plasma membrane (dashed) borders were highlighted and cytoplasmic transcripts counted visually. The 90% confidence interval is shown for a Poisson random variable with mean of 14.