Table 1.
Subjects’ Demographic, Physical and Metabolic Characteristics
| IR | IS | P-value | |
|---|---|---|---|
| Male/female | 4/6 | 4/9 | NS |
| Age (years) | 49±4 | 50±4 | NS |
| BMI (kg/m2) | 30.4±1.2 | 25.8±0.9 | <0.007 |
| Weight (kg) | 89.8±4.8 | 73.1±3.9 | <0.015 |
| Fat mass (kg) | 34.9±2.2 | 25.5±1.8 | <0.004 |
| Lean mass (kg) | 50.4±3.4 | 44.4±3.0 | NS |
| Fasting plasma glucose (mmol/l) | 5.2±0.1 | 4.9±0.1 | 0.06 |
| 2-h plasma glucose OGTT (mmol/l) | 7.6±0.5 | 6.0±0.3 | <0.018 |
| Fasting plasma insulin (pmol/l) | 67.0±5.6 | 21.4±2.8 | <0.001 |
| HbA1c (%) | 5.9±0.1 | 5.5±0.1 | <0.012 |
| Plasma triglycerides (mmol/l) | 1.8±0.2 | 1.0±0.1 | <0.001 |
| Plasma total cholesterol (mmol/l) | 5.0±0.3 | 4.6±0.2 | NS |
| Plasma HDL cholesterol (mmol/l) | 1.2±0.1 | 1.5±0.1 | 0.085 |
| Plasma LDL cholesterol (mmol/l) | 3.1±0.3 | 2.7±0.2 | NS |
| Plasma NEFA (µmol/l) | 1,091±141 | 544±36 | <0.004 |
| Glucose infusion rate in clamp (mg·kg−1·min−1) | 3.7±0.3 | 9.0±0.5 | <0.001 |
| Systolic blood pressure (mmHg) | 128±4 | 118±3 | 0.087 |
| Diastolic blood pressure (mmHg) | 81±3 | 73±2 | 0.068 |
Data are presented as means ± SE