Table 2.
Proteins that were identified in at least 12 of the 23 subjects and that differed significantly (P < 0.05) in abundance by a factor ≥1.5 between the averages of the IR group and the IS group
| Protein Name (Gene name) | Fold change in IR |
Student’s t-test |
Mann Whitney U test |
IR/IS with protein assigned |
Total unshared spectra per group |
|
|---|---|---|---|---|---|---|
| P-value | P-value | IR | IS | |||
| Fatty acid-binding protein, epidermal (FABP5) |
0.14±0.16 | <0.001 | <0.001 | 1/12 | 7 | 54 |
| Hemoglobin subunit beta (HBB) |
0.20±0.22 | <0.009 | <0.013 | 3/10 | 5 | 38 |
| 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) |
0.23±0.15 | <0.001 | <0.001 | 5/13 | 18 | 124 |
| Succinyl-CoA ligase [GDP- forming] subunit beta, mitochondrial (SUCLG2) |
0.33±0.22 | <0.032 | <0.015 | 3/11 | 5 | 28 |
| Histone H3.2 (HIST2H3C; HIST2H3A; HIST2H3D) |
0.34±0.25 | <0.06 | <0.026 | 2/10 | 5 | 19 |
| Cytochrome c (CYCS) | 0.39±0.23 | <0.034 | <0.006 | 4/13 | 11 | 44 |
| Methylmalonate- semialdehyde dehydrogenase, mitochondrial (ALDH6A1) |
0.39±0.15 | <0.005 | <0.005 | 7/13 | 20 | 83 |
| Isoform 2 of
Leucyl-cystinyl aminopeptidase (LNPEP) |
0.39±0.24 | <0.05 | <0.067 | 6/10 | 8 | 31 |
| Abhydrolase domain- containing protein 5 (ABHD5) |
0.40±0.20 | <0.046 | <0.058 | 3/10 | 5 | 19 |
| LETM1 and EF-hand domain-containing protein 1, mitochondrial (LETM1) |
0.43±0.16 | <0.02 | <0.01 | 6/13 | 21 | 79 |
| Medium-chain specific acyl- CoA dehydrogenase, mitochondrial (ACADM) |
0.43±0.21 | <0.05 | <0.036 | 6/13 | 22 | 84 |
| Hemoglobin subunit alpha (HBA2; HBA1) |
0.45±0.22 | <0.047 | <0.022 | 10/12 | 46 | 148 |
| Profilin-1 (PFN1) | 0.46±0.20 | <0.02 | <0.036 | 5/12 | 45 | 140 |
| Succinyl-CoA ligase [GDP- forming] subunit alpha, mitochondrial (SUCLG1) |
0.47±0.18 | <0.038 | <0.022 | 6/12 | 20 | 62 |
| ADP/ATP translocase 2 (SLC25A5) |
0.47±0.22 | <0.076 | <0.026 | 6/10 | 8 | 31 |
| Isoform 1 of Cell division control protein 42 homolog (CDC42) |
0.48±0.17 | <0.049 | <0.058 | 5/11 | 8 | 26 |
| Fatty acid-binding protein, adipocyte (FABP4) |
0.49±0.16 | <0.026 | <0.036 | 9/13 | 528 | 1703 |
| Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) |
0.50±0.12 | <0.01 | <0.006 | 9/13 | 43 | 131 |
| Tricarboxylate transport protein, mitochondrial (SLC25A1) |
0.61±0.15 | <0.047 | <0.026 | 9/13 | 26 | 69 |
| Kinesin-1 heavy chain (KIF5B) |
1.50±0.14 | <0.012 | <0.018 | 10/12 | 75 | 81 |
| Dihydropyridine receptor alpha 2 subunit (CACNA2D1) |
1.56±0.17 | <0.03 | <0.031 | 10/12 | 82 | 81 |
| Septin-7 (SEPT7) | 1.64±0.25 | <0.05 | <0.26 | 10/10 | 40 | 42 |
| Isoform 1 of Atlastin-3 (ATL3) |
1.76±0.31 | <0.04 | <0.036 | 10/12 | 68 | 66 |
| Carbonyl reductase [NADPH] 1 (CBR1) |
1.76±0.30 | <0.075 | <0.031 | 9/9 | 51 | 51 |
| Isoform 2 of Filamin-A (FLNA) |
1.78±0.33 | <0.038 | <0.077 | 10/11 | 197 | 183 |
| Isoform 1 of Spectrin alpha chain, brain (SPTAN1) |
2.05±0.41 | <0.024 | <0.05 | 9/12 | 99 | 95 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) |
2.19±0.40 | <0.024 | <0.026 | 9/8 | 55 | 47 |
| NADH-cytochrome b5 reductase 1 (CYB5R1) |
2.50±0.62 | <0.038 | <0.058 | 7/7 | 12 | 8 |
| Isoform 1 of Liver carboxylesterase 1 (CES1) |
2.63±0.63 | <0.019 | <0.026 | 10/10 | 60 | 36 |
| Tubulin beta-2A chain (TUBB2A) |
2.94±0.80 | <0.017 | <0.05 | 8/9 | 18 | 10 |
Data are presented as means ± SE