Fig. 6.

The effect of ligand treatment on c-fos–positive cell number. (A) Representative image of a spinal cord with c-fos staining plus high-power magnification of the dorsal commissure showing c-fos positivity in a wild-type and knockout mouse. (B) Quantification of c-fos–positive cell numbers in rats. Displayed is the mean number of c-fos–positive cells in the L6–S1 spinal cord (five rats per group). Statistical significance was calculated with one-way analysis of variance with Bonferroni post-test correction. (C) Quantification of c-fos–positive cell numbers in CCL21 atypical receptor knockout mice and wild-type littermates. Displayed is the mean number of c-fos–positive cells in the L6–S1 spinal cord (six wild type, seven knockout). Statistical significance of p = 0.039 was calculated with an unpaired Student t test.

ns = not significant; Tx = treatment.

* p < 0.05.