Figure 3:

Melanoma gene mutation-specific survival analysis at different time points; SNaPshot mutation panel testing began in July 2010. (A) survival curves as of June 2012, 6 months prior to first significant finding; (B) first significant finding, in December 2012, of inferior survival associated with GNAQ mutation; (C) similar results are seen in December 2013; and (D) the most recent analysis, August 2015. BRAF: v-raf murine sarcoma viral oncogene homolog B; CTNNB1: catenin (cadherin-associated protein), beta 1, 88 kDa; GNA11: guanine nucleotide binding protein (G protein), alpha 11 (Gq class); GNAQ: guanine nucleotide binding protein (G protein), q polypeptide; KIT: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; NRAS: neuroblastoma RAS viral (v-ras) oncogene homolog.