Table 3:

The Scoring System That Evaluator Used to Score the Drug Lists

Score	Description
3	Evidence exists to add to reference set (Gene Sheets).
	Criteria:
	Either:
	Drug directly targets and inhibits the gene OR Drug indirectly targets the gene by inhibiting downstream pathway members AND There is evidence that alterations in the gene sensitize cells to drugs inhibiting the indirect target
2	Gene name or its alias is mentioned with the drug or its synonym, but evidence is not sufficient to add to reference set.
	Categories
	High relevance:
	Indirectly targets the gene but there is no level of evidence for its use in tumors with alterations in the gene Partial response Associated with resistance Effective only in combination
	Low relevance:
	Mutation negative (patients negative for mutations in a gene were treated with a drug) Opposite association (text suggests that the gene target affects the drug, rather than vice versa) Discusses an isoform or artificial version of the gene Derivative of the drug is being discussed (not actual drug indicated in evaluation) Association unclear Drug targets molecule upstream of original target (not likely to be effective) No effect
	No relevance:
	Not a drug/not used as a drug No relationship/effect untested Drug is used as a carcinogen/would never be used to treat cancer Opposite effect (the drug results in increased activity of the target gene) Not classified:
1	No mention of the drug and/or gene or its alias.