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. 2016 May 26;16(7):737–749. doi: 10.1080/14737159.2016.1181545

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© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — Frequency of mutations/genomic alterations in NSCLC (adenocarcinoma) in Caucasian populations, and known mutation profiles in ALK and EGFR TKI-resistant disease. ALK: anaplastic lymphoma kinase; BRAF: v-Raf murine sarcoma viral oncogene homolog B; EGFR: epidermal growth factor receptor; EML4: echinoderm microtubule-associated protein-like 4; EMT: epithelial-mesenchymal transition; HER2: human epidermal growth factor receptor 2; KRAS: Kirsten Rat Sarcoma viral oncogene homolog; MEK: mitogen-activated protein kinase kinase; NTRK: neurotrophic tyrosine kinase receptor; PIK3CA: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; RET: rearranged during transfection; ROS1: ROS proto-oncogene 1, receptor tyrosine kinase; SCLC: small-cell lung carcinoma; TKI: tyrosine kinase inhibitor.