Figure 2.

Effects of phencyclidine (PCP) on motor activity and motor sensitization in D32 ^F/F D1RCre ⁺ mice. (A, C) D1RCre mice and (B, D) D32 ^F/F D1RCre ⁺ conditional knockout mice were injected with vehicle or PCP (3mg/kg) for 7 consecutive days. Motor activity (measured as distance covered in cm) was measured on (A, B) Day 1 and (C, D) Day 7, during two consecutive sessions of 60min, immediately preceding (habituation, grey) and following injection of vehicle (open circles) or PCP (filled circles). Note the absence of acute motor response (Day 1; B) and motor sensitization (Day 7; D) to PCP in D32 ^F/F D1RCre ⁺ mice in comparison to D1RCre control mice (A, C). Data are expressed as mean ± standard error of the mean (n = 5–8/group).