Figure 3.

Effects of phencyclidine (PCP) on motor activity and motor sensitization in D32 ^F/F D2RCre ⁺ mice. (A, C) D2RCre mice and (B, D) D32 ^F/F D2RCre ⁺ conditional knockout mice were injected with vehicle or PCP (3mg/kg) for 7 consecutive days. Motor activity (measured as distance covered in cm) was measured on (A, B) Day 1 and (C, D) Day 7, during two consecutive sessions of 60min, immediately preceding (habituation, grey) and following injection of vehicle (open circles) or PCP (filled circles). Data are expressed as mean ± standard error of the mean (n = 5–8/group).