Fig. 5.

Maximum bone mineral density. Mice from 2 to 8 weeks of age were scanned on the eXplore speCZT system at 50 μm and re-binned to 100 μm for these analyses. Mice from 11 to 52 weeks of age were scanned on the eXplore Locus Ultra system at 154 μm nominal voxel spacing, as described in the legends of Fig. 1, Fig. 2. Left femurs were cropped from the whole-body images and axes were reoriented. A region of interest (ROI) that encompassed the mid-diaphysis in all three spatial directions was cropped from each of the volumes. The ROI, which included only cortical bone, was then used to determine the maximum value of BMD. Data are means ± S.D., n = 7 mice per age group. The curve was fit by non-linear least squares regression.