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. 2016 Jun 15;30(12):1409–1422. doi: 10.1101/gad.282277.116

Figure 3.

Figure 3.

Screen of methionine metabolism components for life span regulation. (A) RNAi screen results ordered by ascending life span. Each bar represents the difference ([black bars] median; [gray bars] mean) in life span between ActinGS>RNAi flies and ActinGS>RNAi flies fed with RU486 starting at day 7. (*) P < 0.05; (**) P < 0.01. (B) Ubiquitous adult-onset expression of Rheb RNAi increases life span in males. P < 0.0001. (C) Ubiquitous adult-onset expression of dAhcyL1 RNAi increases life span in males. P < 0.0001 (for both 1× and 2× concentrations of RU486). (D) Ubiquitous adult-onset expression of dAhcyL1 RNAi-2 increases life span in females. P < 0.0001 (for both 1× and 2× concentrations of RU486). (E) Ubiquitous adult-onset expression of dAhcyL1 RNAi-1 (HM05009) increases life span in males. P < 0.0001. (F) Ubiquitous adult-onset expression of dAhcyL2 RNAi-1 increases life span in males. P < 0.0001. (G) Ubiquitous adult-onset expression of dAhcyL2 RNAi-2 increases life span in males. P < 0.0001.