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. 2016 Jun 15;30(12):1409–1422. doi: 10.1101/gad.282277.116

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© 2016 Parkhitko et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — dAhcyL1 and dAhcyL2 are involved in the regulation of methionine metabolism. (A) Scheme of methionine metabolism regulation by dAhcyL1 and dAhcyL2. (B) Relative levels of SAH in tubulinGal80ts, tubulinGal4 flies expressing either control (gfp) or Ahcy13 RNAi-1 for 2 wk at 29.5°C. (***) P < 0.0001. Means ± SD. (C) Relative levels of SAH in tubulinGal80ts, tubulinGal4 flies expressing either control (gfp) or dAhcyL1 RNAi-1 for 2 wk at 29.5°C. (*) P < 0.05. Means ± SD. (D) Relative levels of homocysteine in tubulinGal80ts, tubulinGal4 flies expressing either control (gfp) or dAhcyL1 RNAi-1 for 2 wk at 29.5°C. (*) P < 0.05. Means ± SD. (E) Ubiquitous adult-onset expression of Ahcy13 RNAi-2 significantly suppresses life span in males. P < 0.001. (F) Ubiquitous adult-onset expression of Ahcy13 RNAi-1 significantly suppresses life span in males. P < 0.001. (G) Brain-specific adult-onset expression of Ahcy13 RNAi-1 significantly suppresses life span in males. P < 0.001. (H) Feeding adult flies with SAM significantly suppresses life span in males. P < 0.001. (I) Feeding adult flies with 100 µM cycloleucine significantly increases life span in males. P < 0.001.