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. 2016 Jun 15;30(12):1409–1422. doi: 10.1101/gad.282277.116

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© 2016 Parkhitko et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 7. — dAhcyL1 and dAhcyL2 are involved in the regulation of H3K4me3 levels. (A) Immunoblot analysis of H3K4me3 and total histone 3 in ActinGS-Gal4>dAhcyL1 RNAi-1 or control RNAi flies fed with RU486 from 7 to 40 d of age. (B) Relative mRNA levels of dAhcyL1, ENOPH1, SMS, and MTAP from 40-d-old ActinGS-Gal4>dAhcyL1 RNAi-1 flies fed with RU486 from 7 to 40 d of age. (*) P < 0.05; (**) P < 0.01. Means ± SD. (C) Ubiquitous adult-onset expression of dAhcyL1 RNAi-1 increases life span in males under a standard sugar/yeast diet (1× SY) P < 0.001 but not with a diet where amounts of sugar and yeast were reduced (0.5× SY). (D) Ubiquitous adult-onset expression of dAhcyL1 RNAi-1 increases life span in males maintained on a high-methionine diet (4.5 g/L). (E) Working model.