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. 2016 Jun 15;30(12):1440–1453. doi: 10.1101/gad.277178.115

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© 2016 Zhou et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — Ino80 occupies genomic regions near melanoma-related genes. (A) Ino80 peak distribution in the genome. (B,C) Heat maps showing Ino80, Med1, H3K27ac, and H3K4me1 occupancy in the BRAF mutant A375 cells (B) or NRAS mutant SK-MEL-147 cells (C). Genes were sorted based on the Ino80 signal around the Ino80 peak center. (D) Genome browser showing Ino80, Med1, and H3K27ac occupancy near representative SE genes in A375 and SK-MEL-147 melanoma cells and in primary melanocytes. (E–H) Dependency of Ino80 occupancy on MITF and Sox9. MITF or Sox9 was silenced by lentiviral shRNAs in A375 cells (E,G), and the Ino80 occupancy at selected genes was determined by ChIP-qPCR (F,H).