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. 2016 Jun 15;30(12):1440–1453. doi: 10.1101/gad.277178.115

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© 2016 Zhou et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 7. — INO80 regulates nucleosome occupancy and Mediator recruitment at oncogenic SEs. (A) Genome tracks showing nucleosome occupancy at SEs near melanoma-related genes in NT versus Ino80 knockdown A375 cells. (B) Average ATAC-seq nucleosome-associated read density at Ino80-bound regions in NT versus Ino80 knockdown A375 cells. The P-values were calculated by Student's t-test. (C) Genome browser tracks showing Med1 and Pol II occupancy at SEs near selected melanoma-related genes in NT or Ino80 knockdown A375 cells. (D) Average ChIP-seq read density of Med1 around the Med1 peak center on SEs versus REs in NT or Ino80 knockdown A375 cells. (E) Box plot of Med1 ChIP-seq read density on SEs versus REs in NT or Ino80 knockdown A375 cells. (F) GSEA of SE-associated genes in genes that are highly expressed in melanoma compared with melanocytes. SEs are defined by Med1 occupancy alone or Med1 and Ino80 co-occupancy.