Table 1.

Available and approved substances for HCV treatment in the Western world

Pegylated interferon alpha 2a and 2b

Ribavirin

NS3/4A protease inhibitors

First wave (associated with numerous side effects and high pill burden)

Telaprevir

Boceprevir

Second wave (improved tolerability and once-daily dosing)

Simeprevir

Paritaprevir (ritonavir-boosted)

NS5A inhibitors

Daclatasvir

Ledipasvir

Ombitasvir

Nucleotide NS5B polymerase inhibitor

Sofosbuvir

Non-nucleoside NS5B polymerase inhibitor

Dasabuvir