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. 2015 Nov 3;27(7):1933–1942. doi: 10.1681/ASN.2015020203

Figure 5.

Figure 5.

Treg-specific ablation of CXCR3 resulted in an aggravated course of crescentic GN. (A) Representative periodic acid–Schiff staining of renal cortices from control (n=4), nephritic Foxp3eGFP-Cre × Cxcr3wt/wt (n=9–12), and nephritic Foxp3eGFP-Cre × Cxcr3fl/fl (n=12–13) mice at day 30. Original magnification, ×200. (B) Crescent formation and tubulointerstitial damage, (C) BUN levels, and (D) albumin-to-creatinine ratio (ACR). (E) Crescent formation and tubulointerstitial damage, (F) BUN levels, and (G) ACR of control (n=4), nephritic Foxp3eGFP-Cre × Cxcr3wt/wt (n=6), and nephritic Foxp3eGFP-Cre × Cxcr3fl/fl (n=6) mice treated with anti-IFNγ antibodies (500 μg two times per week intraperitoneally until day 30). Symbols represent individual data points, and lines represent means. Con, control. *P<0.05; **P<0.01.