Figure 6.

Transferred CXCR3–deficient Tregs fail to control GN in RAG1^−/− mice. (A) Representative periodic acid–Schiff-stained kidney sections of RAG1^−/− control and nephritic RAG1^−/− mice reconstituted with 1×10⁶ CD4⁺CD25⁻ effector T cells without Tregs, 1×10⁶ CD4⁺CD25⁻ effector T cells, 5×10⁵ FACS–sorted Foxp3^eGFP-Cre × Cxcr3^wt/wt Tregs, or Foxp3^eGFP-Cre × Cxcr3^fl/fl Tregs. Original magnification, ×200. (B) Quantification of glomerular crescent formation and tubulointerstitial injury in the different groups at day 30 after NTN induction (n=3–5 per group). Bars represent means±SEMs. WT, wild type. *P<0.05.