Figure 2.
Treatment with 2DG ameliorates cystic kidney disease in the medium-term model. (A) Images of cystic kidneys treated with 2DG at 100 mg/kg or NaCl from P12 to P26 and littermates controls. The best example is shown (litter 2). (B) The percentage of kidney weight to total body weight in cystic mice treated as described in A was significantly reduced compared with the vehicle control (NaCl). The same treatment had no effect on the percentage of kidney to total body weight in control mice. The power of the study was 0.94. (C) Representative images of the histologic analysis of kidneys treated as described in A. (D) Cystic index calculated for the kidneys from Pkd1ΔC/floxTmCre mice treated with 2DG or vehicle as described in A–C. Means±SEMs are indicated. NS indicates P≥0.05. Scale bars, 4 mm in A; 1 mm in C. *P<0.05 determined using the Mann–Whitney test for B and D; **P<0.01 determined using the Mann–Whitney test for B and D.