. 2016 Jan 28;27(7):2164–2176. doi: 10.1681/ASN.2015040369

Table 1.

Metabolic parameters, renal function, BP, and requirements for antihypertensive treatment in study arms

Parameter and Study Moment	KD (n=104)	LPD (n=103)	P Value^c
Renal function
eGFR (ml/min)
Baseline	18.0 (15.5 to 20.1)	17.9 (14.3 to 19.3)	0.68
End of study	15.1 (13.2 to 17.4)	10.8 (9.0 to 12.2)	<0.01
Proteinuria (g/d)^a
Baseline	0.88 (0.79 to 0.96)	0.88 (0.82 to 0.96)	0.73
End of study	0.78 (0.67 to 0.85)	0.67 (0.57 to 0.81)	0.06
BP^b
Mean arterial BP (mmHg)
Baseline	86 (78 to 96)	93 (86 to 96)	0.06
End of study	90 (86 to 92)	87 (83 to 93)	0.42
Patients with optimal BP control^c (%)
Baseline	91	89	0.67
End of study	85	84	0.95
Patients on antihypertensive drugs (%)
Baseline	86	89	0.55
End of study	88	93	0.24
Patients receiving ACEIs and/or ARBs (%)
Baseline	71	71	0.96
End of study	71	70	0.84
Nitrogen waste products
Serum urea (mg/dl)^d
Baseline	187 (164 to 225)	213 (183 to 248)	0.73
End of study	122 (114 to 127)	226 (191 to 252)	<0.01
Serum uric acid (mg/dl)^e
Baseline	6.5 (6.5 to 6.6)	6.3 (6.2 to 6.3)	0.06
End of study	6.0 (5.8 to 6.1)	6.3 (6.1 to 6.4)	0.01
Acid-base balance
Serum bicarbonate (mEq/L)
Baseline	16.7 (15.8 to 17.6)	16.8 (15.9 to 17.8)	0.98
End of study	22.9 (21.7 to 24.1)	16.2 (15.4 to 16.9)	<0.01
Sodium bicarbonate supplementation
Patients treated (%)
Baseline	36	40	0.53
End of study	29	51	<0.01
Prescribed dose (g/d)
Baseline	2.0 (2.0 to 2.4)	2.0 (1.6 to 2.4)	0.63
End of study	2.2 (2.0 to 2.6)	3.2 (2.4 to 3.6)	0.03
Calcium-phosphorus metabolism
Serum calcium (mg/dl)
Baseline	3.8 (3.7 to 3.9)	3.8 (3.7 to 4.0)	0.61
End of study	4.4 (4.3 to 4.5)	3.9 (3.7 to 3.9)	<0.01
Serum phosphates (mg/dl)
Baseline	5.9 (5.3 to 6.2)	5.8 (5.2 to 6.1)	0.68
End of study	4.4 (4.3 to 4.5)	6.2 (5.8 to 6.5)	<0.01
Calcium supplementation
Patients treated (%)
Baseline	46	40	0.35
End of study	49	51	0.72
Prescribed dose (g/d)
Baseline	6.1 (5.7 to 6.5)	6.0 (5.6 to 6.5)	0.91
End of study	6.3 (6.0 to 6.6)	6.9 (6.6 to 7.3)	<0.01
Vitamin D therapy (patients %)
Baseline	22	30	0.19
End of study	22	54	<0.01

Values at randomization were compared with those at the end of the study (i.e., reach of the EPP or end of the follow-up period). Data are shown as median and 95% CI. To convert eGFR in milliliters per minute to milliliters per second, multiply by 0.01667. To convert serum urea in milligrams per deciliter to millimoles per liter, multiply by 0.357. To convert serum urea in milligrams per deciliter to BUN in milligrams per deciliter, divide by 2.14. To convert serum creatinine in milligrams per deciliter to ± moles per liter, multiply by 88.4. To convert serum bicarbonate in equivalents per liter to millimoles per liter, multiply by 1. To convert serum calcium in milligrams per deciliter to millimoles per liter, multiply by 0.2495. To convert serum phosphates in milligrams per deciliter to millimoles per liter, multiply by 0.3229. To convert serum albumin in grams per deciliter to grams per liter, multiply by 10.