Table 2.
Risk factors for TRIs
| Risk Factor | TRI+ (n=41; %) | TRI− (n=82; %) | P Value |
|---|---|---|---|
| Traditional risk factors | |||
| Viral infection | |||
| Total | 12 (29.3) | 12 (13.4) | 0.09 |
| EBV | 4 (9.8) | 4 (4.9) | |
| Hepatitis C | 3 (7.3) | 0 | |
| Hepatitis E | 1 (2.4) | 0 | |
| CMV | 1 (2.4) | 2 (2.4) | |
| EBV + CMV | 1 (2.4) | 0 | |
| BK | 2 (4.9) | 5 (6.1) | |
| HIV | 0 | 1 (1.2) | |
| Malignancy, total | 2 (4.9) | 2 (2.4) | 0.60 |
| Autoimmune | |||
| Total | 8 (19.5) | 10 (12.2) | 0.42 |
| Low C3 or C4 | 4 (9.8) | 4 (4.9) | |
| dsDNA | 2 (4.9) | 2 (2.4) | |
| PR3/ACA | 1 (2.4) | 0 | |
| MPO | 1 (2.4) | 1 (1.2) | |
| PR3 | 0 | 3 (3.7) | |
| Infection | |||
| Total | 3 (7.3) | 4 (4.9) | 0.68 |
| UTI | 3 (7.3) | 4 (4.9) | |
| Alloimmune risk factors | |||
| DSAs | |||
| Yes | 20 (48.8) | 20 (24.4) | 0.01 |
| No | 21 (51.2) | 62 (75.6) | |
| HLA class | |||
| Class 1 alone | 8 (19.5) | 8 (9.8) | 0.03 |
| Class 2 alone | 7 (17.1) | 9 (11.0) | 0.09 |
| Classes 1 and 2 | 5 (12.2) | 3 (3.7) |
Epstein-Barr virus; BK, BK virus; dsDNA, double stranded DNA; PR3, proteinase-3 antibodies; ACA, anticardiolipin antibodies; MPO, myeloperoxidase antibodies; UTI, urinary tract infection.