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. 2015 Nov 3;27(7):1984–1995. doi: 10.1681/ASN.2015060610

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Figure 5. — S1P1 functions intrinsically to regulate renal vascular development. (A and B) X-gal staining and immunostaining for myosin heavy chain on sections from transplanted embryonic kidneys of control (A) and iEC-SCL-S1P1KO (B) mice showed increased number of β-gal+ ECs and dilated vessels (thin arrow) in the iEC-SCL-S1P1KO kidneys. (C and D) Control kidneys under transplantation showed normal development of glomerular capillaries (C, dotted circle) whereas iEC-SCL-S1P1KO kidneys developed capillary shunts (CS) (D, arrow). (E and F) Control kidneys under transplantation developed normal arterioles (E), whereas iEC-SCL-S1P1KO kidneys showed dilated arteriolar lumen (F, arrow). Scale bars: 200 μm (A and B) and 50 μm (C–F).