Figure 7.

SCL+ precursors contribute to hemovasculogenesis in the kidney. Summary of findings on the lineage relationship between the SCL+ precursors and the renal vascular endothelium and blood cells in the early embryo. Blue arrows indicate the lineage relationship from our results, and black arrows show published data from other groups. (A) The SCL+ precursor gives rise to definitive (light blue cells) and hemogenic (dark blue cells) vascular endothelium of renal vessels, including renal arteries, veins (not shown), glomerular capillaries, and peritubular capillaries. (B) S1P-S1P1 signaling between blood cells and ECs derived from SCL+ precursors regulates kidney vascular development. Endothelial S1P1 is involved in mural cell coating of renal arteries and arterioles and development of glomerular capillaries and lymphatic ECs and inhibits renal EC proliferation.