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. 2015 Nov 16;27(7):2082–2091. doi: 10.1681/ASN.2015070796

Figure 2.

Figure 2.

Acetazolamide (Acz) attenuates lithium (Li+)-induced NDI in mice. (A) Urine volume, (B) water intake, and (C) urine osmolality of untreated mice (control [Ctr]) or mice treated for 10 days with Li+ or Li+ combined with thiazide/amiloride (T+Am) or Acz. During the last 48 hours, mice were housed in metabolic cages; during the last 24 hours, water intake was measured, and urine was collected to determine urine volume and osmolality (n=8 mice per group; one-way ANOVA and Bonferroni multiple comparison test). *P<0.05.