Table 3.
Classification of infertility risk induced by chemotherapy in males.
| CHEMOTHERAPY TREATMENT | EFFECT ON SPERM COUNT |
|---|---|
| Chlorambucil (1.4 g/m2) Cyclophosphamide (19 g/m2) Procarbazine (4 g/m2) Melphalan (140 mg/m2) Cisplatin (500 mg/m2) |
Prolonged or permanent azoospermia |
| BCNU (1 g/m2) CCNU (500 mg/m2) |
Azoospermia in adulthood if treated before puberty |
| Busulfan (600 mg/m2) Ifosfamide (42 g/m2) BCNU (300 mg/m2) Nitrogen mustard |
Azoospermia likely, and are often given with other highly sterilizing agents, adding to the effect |
| Doxorubicin (770 mg/m2) Thiotepa (400 mg/m2) Cytarabine (1 g/m2) Vinblastine (50 g/m2) Vincristine (8 g/m2) |
When used alone, cause only temporary reductions in sperm count. In conjunction with above agents, may be additive in causing azoospermia |
| Amsacrine Bleomycin Dacarbazine Daunorubicin Epirubicin Etoposide Fludarabine Fluorouracil 6-mercaptopurine Methotrexate Mitoxantrone Thioguanine |
When used in conventional regimens, cause only temporary reductions in sperm count. In conjunction with above agents, may be additive in causing azoospermia |