Figure 5.

Synaptic endocannabinoid signaling. Dashed arrows indicate inactivation of endocannabinoid.

Abbreviations: AA, arachidonic acid; DAGs, diacylglycerols; ER, endoplasmic reticulum; MAPK, mitogen-activated protein kinases; PIP2, phosphoinositide bisphosphate; PKA, protein kinase A; PLCβ, phospholipase Cβ; PPARs, peroxisome proliferator-activated receptors; TRPs, transient receptor potential channels; VGCCs, voltage-gated calcium channels.

Note: Reprinted by permission from Macmillan Publishers Ltd: Nature Reviews Neuroscience, copyright 2015.⁴⁴