Table 3.

C3 analogs of ∆8-THC and ∆9-THC.

#		CB	NAME	CB1 KI (nM)	CB2 KI (nM)	FUNCTIONAL	REF
64		Δ8-THC	AM735	8.9 ± 1.0	7.4 ± 0.8		97
65		Δ8-THC	AM731	60.2 ± 0.8	6.1 ± 0.6		97
66		Δ8-THC	AM411	6.80	52.0	Agonist	93
67		Δ8-THC	AM744	34.9	14.0	Agonist	93
68		Δ8-THC	AM757	79.7	76.0	Agonist	93
69		Δ8-THC		95.5 ± 16.7	71.8 ± 12.2		140
70		Δ8-THC		11.7 ± 1.6	9.4 ± 1.5		140
71		Δ8-THC	KM-233	12.3 ± 0.6	0.9 ± 0.1		141
72		Δ8-THC		76.1 ± 1.5	12.4 ± 0.2		141
73		Δ8-THC		18.8 ± 1.4	1.7 ± 0.2		141
74		Δ8-THC		5.03 ± 0.4	1.5 ± 0.2		141
75		Δ8-THC		3.1 ± 0.4	0.9 ± 0.1		141
76		Δ8-THC		5.3 ± 0.9	0.9 ± 0.02		141