Table 2.

Biodistribution of [¹²⁵I]PYK in nude mice at 24h post-injection (%ID/g)^a

Tissue	Xenograft of cell lines
	U87MG.AEGFR	U87MG.DK	U87MG.wtEGFR	U87MG
Tumor	0.17 ± 0.06	0.24 ± 0.16	0.18 ± 0.07	0.15 ± 0.02
Blood	0.05 ± 0.01	0.05 ± 0.00	0.05 ± 0.01	0.05 ± 0.01
Pancreas	0.06 ± 0.03	0.20 ± 0.02	0.15 ± 0.04	0.21 ± 0.02
Spleen	0.12 ± 0.00	0.16 ± 0.01	0.13 ± 0.01	0.17 ± 0.03
Stomach	0.62 ± 0.56	0.38 ± 0.54	0.54 ± 0.47	0.64 ± 0.80
Small intestine	0.59 ± 0.28	0.87 ± 0.13	0.79 ± 0.52	1.01 ± 0.23
Colon	1.69 ± 0.41	5.32 ± 1.22	3.26 ± 1.49	5.57 ± 0.96
Liver	0.42 ± 0.14	0.47 ± 0.05	0.48 ± 0.12	0.55 ± 0.09
Kidney	0.30 ± 0.05	0.32 ± 0.03	0.25 ± 0.04	0.34 ± 0.02
Heart	0.09 ± 0.02	0.11 ± 0.01	0.08 ± 0.01	0.09 ± 0.01
Lung	0.17 ± 0.04	0.21 ± 0.08	0.16 ± 0.01	0.22 ± 0.03
Brain	0.03 ± 0.01	0.03 ± 0.00	0.02 ± 0.01	0.03 ± 0.01
Muscle	0.05 ± 0.01	0.08 ± 0.05	0.06 ± 0.02	0.07 ± 0.01
Bone	0.31 ± 0.07	0.32 ± 0.05	0.36 ± 0.15	0.37 ± 0.15
Uptake ratio b
Brain/Blood	0.64 ± 0.17	0.56 ± 0.03	0.48 ± 0.17	0.61 ± 0.13
Tumor/Muscle	3.78 ± 1.09	4.23 ± 3.47	3.29 ± 1.83	2.16 ± 0.33
Tumor/Blood	3.90 ± 1.67	4.71 ± 3.25	3.89 ± 1.67	2.95 ± 0.60

^aThe data are expressed as Mean % injection dose ± S.D. per gram, n=4

^bRatio of brain to blood or tumor-to-normal tissue.