Fig 5. Drug resistance mutation frequency comparison, 2000–2005 vs. 2006–2015, for the Mesoamerican region.

Drug resistance mutation frequency is shown for the studies included in the meta-analysis. Only surveillance mutations included in the WHO list are shown, ordered by drug family. *Significant differences (p<0.05), Fisher’s exact test. NRTI–nucleoside reverse transcriptase inhibitors; NNRTI–non-nucleoside reverse transcriptase inhibitors; PI–protease inhibitors.