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. Author manuscript; available in PMC: 2016 Jun 29.
Published in final edited form as: Science. 2015 Oct 22;350(6262):826–830. doi: 10.1126/science.aab3145

Fig. 1. Nlrp6 controls EMCV infection of the intestine.

Fig. 1

(A) The survival curves of WT and Nlrp6−/− mice infected with EMCV via the intra-peritoneal route (i.p.). N=12/group. Quantitative PCR analyses of (B) EMCV viral loads and (C) Nlrp6 in various tissues 72 hours after infection with EMCV i.p. IEC: isolated intestinal epithelial cells from infected intestines. (D) The survival curves of WT mice, WT mice cohoused with Nlrp6−/− [WT (Nlrp6−/−)], Nlrp6−/− mice cohoused with WT [Nlrp6−/−(WT)] and Casp1−/− mice after oral infection with EMCV. N=10–16/group, *P<0.05 (Log-rank test). Results were pooled from two independent experiments. Quantitative PCR analysis of EMCV loads (E) in the whole blood cells 72 hours after oral infection or (F) intestines 72 hours after i.p. infection. Each symbol in (B), (C), (E) and (F) represents one mouse; small horizontal lines indicate the median of the result. *P < 0.05, **P < 0.01 (nonparametric Mann-Whitney analysis). The data are representative of at least 2–3 independent experiments.