Table 2. Model 2—Multivariate regression results showing significant associations of plasma biomarker with HIV clinical parameters, CVD risk age, gender, ethnicity and smoking after adjusting for CXCL10, sCD163 and sCD14.
| Biomarker | CXCL10 | sCD163 | sCD14 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | β | std error | p | β | std error | p | β | std error | p |
| Age at 2010 | - | - | - | 0.002 | 0.001 | 0.03 | 0.001 | 0.0006 | 0.08 |
| Gender | - | - | - | - | - | - | 0.031 | 0.018 | 0.08 |
| Ethnicity | -0.15 | 0.046 | 0.001 | 0.107 | 0.042 | 0.012 | -0.058 | 0.022 | 0.009 |
| Gender:Ethnicity | -0.224 | 0.063 | 0.0004 | - | - | - | - | - | - |
| Smoking | - | - | - | - | - | - | 0.043 | 0.015 | 0.004 |
| Residual viraemia | - | - | - | 0.058 | 0.026 | 0.025 | - | - | - |
| VL5 | 0.28 | 0.058 | <0.0001 | - | - | - | 0.07 | 0.023 | 0.002 |
| SQR CD4:8 | -0.202 | 0.080 | 0.012 | - | - | - | - | - | - |
| SQR CD4 | -0.01 | 0.003 | 0.0005 | - | - | - | -0.002 | 0.001 | 0.07 |
| NRTI | -0.156 | 0.046 | 0.0007 | - | - | - | - | - | - |
| NNRTI | - | - | - | - | - | - | 0.052 | 0.018 | 0.004 |
| PI | - | - | - | - | - | - | 0.041 | 0.018 | 0.026 |
| Integrase | - | - | - | - | - | - | -0.078 | 0.037 | 0.037 |
| HDL | - | - | - | -0.04 | 0.023 | 0.09 | - | - | - |
| BMI | - | - | - | 0.004 | 0.002 | 0.017 | - | - | - |
| Framingham score | - | - | - | 0.05 | 0.025 | 0.049 | - | - | - |
| CXCL10 | - | - | - | 0.18 | 0.026 | <0.0001 | -0.023 | 0.022 | 0.3 |
| sCD163 | 0.51 | 0.079 | <0.0001 | - | - | - | 0.13 | 0.039 | 0.0009 |
| sCD14 | -0.06 | 0.096 | 0.53 | 0.16 | 0.056 | 0.003 | - | - | - |
“-“p = >0.01; std = standard error.