Table 2. Model 2—Multivariate regression results showing significant associations of plasma biomarker with HIV clinical parameters, CVD risk age, gender, ethnicity and smoking after adjusting for CXCL10, sCD163 and sCD14.
Biomarker | CXCL10 | sCD163 | sCD14 | ||||||
---|---|---|---|---|---|---|---|---|---|
Variable | β | std error | p | β | std error | p | β | std error | p |
Age at 2010 | - | - | - | 0.002 | 0.001 | 0.03 | 0.001 | 0.0006 | 0.08 |
Gender | - | - | - | - | - | - | 0.031 | 0.018 | 0.08 |
Ethnicity | -0.15 | 0.046 | 0.001 | 0.107 | 0.042 | 0.012 | -0.058 | 0.022 | 0.009 |
Gender:Ethnicity | -0.224 | 0.063 | 0.0004 | - | - | - | - | - | - |
Smoking | - | - | - | - | - | - | 0.043 | 0.015 | 0.004 |
Residual viraemia | - | - | - | 0.058 | 0.026 | 0.025 | - | - | - |
VL5 | 0.28 | 0.058 | <0.0001 | - | - | - | 0.07 | 0.023 | 0.002 |
SQR CD4:8 | -0.202 | 0.080 | 0.012 | - | - | - | - | - | - |
SQR CD4 | -0.01 | 0.003 | 0.0005 | - | - | - | -0.002 | 0.001 | 0.07 |
NRTI | -0.156 | 0.046 | 0.0007 | - | - | - | - | - | - |
NNRTI | - | - | - | - | - | - | 0.052 | 0.018 | 0.004 |
PI | - | - | - | - | - | - | 0.041 | 0.018 | 0.026 |
Integrase | - | - | - | - | - | - | -0.078 | 0.037 | 0.037 |
HDL | - | - | - | -0.04 | 0.023 | 0.09 | - | - | - |
BMI | - | - | - | 0.004 | 0.002 | 0.017 | - | - | - |
Framingham score | - | - | - | 0.05 | 0.025 | 0.049 | - | - | - |
CXCL10 | - | - | - | 0.18 | 0.026 | <0.0001 | -0.023 | 0.022 | 0.3 |
sCD163 | 0.51 | 0.079 | <0.0001 | - | - | - | 0.13 | 0.039 | 0.0009 |
sCD14 | -0.06 | 0.096 | 0.53 | 0.16 | 0.056 | 0.003 | - | - | - |
“-“p = >0.01; std = standard error.