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. 2016 Jun 29;11(6):e0158305. doi: 10.1371/journal.pone.0158305

Fig 10. Model simulations of [ATPe] kinetics.

Fig 10

(A) The lines represent the best fit of the model to experimental ATPe kinetics for rbcs exposed to MST7 in isosmotic and hyperosmotic media. Two ATP conduits were assumed to mediate ATP efflux. The model was run assuming that one (dashed lines) or both conduits (continuous lines) were sensitive to swelling. Experimental data was obtained from Fig 3B, and showed only for comparison. (B) The lines represent the best fit of the model to experimental ATPe kinetics for rbcs exposed to MST7 in the absence and presence of 10 μM CBX. Two Vr-sensitive ATP conduits were assumed. The model was run assuming that CBX blocked one ATP conduit and partially inhibited the second conduit. Experimental data was obtained from Fig 2B, and showed only for comparison. MST7 is added at t = 20 min. The model is described in S1 File, with best fitting values shown in Table A in S1 File.