Table 2. Impact of health-related quality of life and social functioning on treatment uptake, adherence and SVR.
| Outcome | Characteristic | n (%) | Univariable model | Multivariable model | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | p value | AOR (95% CI) | p value | |||
| Treatment uptake, n = 145 | Physical HRQoL | |||||
| Lower (≤50th centile) | 19 (75%) | 1 | – | 1 | – | |
| Higher (>50th centile) | 68 (78%) | 1.19 (0.52–2.73) | 0.676 | 0.86 (0.35–2.13) | 0.7521 | |
| Mental HRQoL | ||||||
| Lower (≤50th centile) | 62 (71%) | 1 | – | 1 | – | |
| Higher (>50th centile) | 42 (88%) | 2.82 (1.07–7.47) | 0.037 | 2.60 (0.93–7.29) | 0.0691 | |
| Social functioning, binary | ||||||
| Lower (≥12 OTI score) | 45 (69%) | 1 | – | 1 | – | |
| Higher (<12 OTI score) | 56 (84%) | 2.26 (0.98–5.21) | 0.055 | 2.31 (0.91–5.81) | 0.0771 | |
| Social functioning, highest v lowest tertile | ||||||
| Lowest (≥15 OTI score) | 32 (67%) | 1 | – | 1 | – | |
| Highest (<10 OTI score) | 42 (86%) | 3.00 (1.10–8.15) | 0.031 | 3.43 (1.01–11.64) | 0.0481 | |
| Treatment adherence, n = 111 | Physical HRQoL | |||||
| Lower (≤50th centile) | 27 (75%) | 1 | – | 1 | – | |
| Higher (>50th centile) | 59 (87%) | 2.19 (0.78–6.12) | 0.137 | 1.60 (0.54–4.77) | 0.4032 | |
| Mental HRQoL | ||||||
| Lower (≤50th centile) | 54 (87%) | 1 | – | 1 | – | |
| Higher (>50th centile) | 32 (76%) | 0.47 (0.17–1.32) | 0.154 | 0.43 (0.15–1.26) | 0.1242 | |
| Social functioning, binary | ||||||
| Lower (≥12 OTI score) | 36 (80%) | 1 | – | 1 | – | |
| Higher (<12 OTI score) | 48 (86%) | 1.50 (0.53–4.27) | 0.447 | 1.11 (0.37–3.35) | 0.8512 | |
| Social functioning, highest v lowest tertile | ||||||
| Lowest (≥15 OTI score) | 25 (78%) | 1 | – | 1 | – | |
| Highest (<10 OTI score) | 36 (86%) | 1.68 (0.50–5.60) | 0.398 | 1.09 (0.29–4.08) | 0.8932 | |
| Sustained virological response, n = 111 | Physical HRQoL | |||||
| Lower (≤50th centile) | 23 (64%) | 1 | 1 | |||
| Higher (>50th centile) | 40 (59%) | 0.81 (0.35–1.86) | 0.615 | 0.88 (0.37–2.10) | 0.7783 | |
| Mental HRQoL | ||||||
| Lower (≤50th centile) | 41 (66%) | 1 | 1 | |||
| Higher (>50th centile) | 22 (52%) | 0.56 (0.25–1.26) | 0.161 | 0.62 (0.27–1.44) | 0.2693 | |
| Social functioning, binary | ||||||
| Lower (≥12 OTI score) | 20 (44%) | 1 | 1 | |||
| Higher (<12 OTI score) | 40 (71%) | 3.13 (1.37–7.14) | 0.007 | 4.37 (1.52–12.55) | 0.0063 | |
| Social functioning, highest v lowest tertile | ||||||
| Lowest (≥15 OTI score) | 13 (41%) | 1 | 1 | |||
| Highest (<10 OTI score) | 28 (67%) | 2.92 (1.13–7.59) | 0.027 | 5.11 (1.30–20.15) | 0.0203 | |
1Adjusted for HIV status and independent predictors of treatment uptake: duration of infection at screening, and HCV RNA log viral load [34].
2Adjusted for HIV status and independent predictors of treatment adherence >80%: education level [35].
3Adjusted for HIV status and independent predictors of SVR: IFNL4 genotype, gender, duration of infection, HCV RNA level and current opiate substitution therapy [5].