Table 4. Factors associated with longitudinal social functioning score (lower score corresponds to higher functioning), (n = 146).

Characteristic	Univariable model		Multivariable model
	coeff. (95% CI)	p value	$\widehat{\text{a}}$ coeff. (95% CI)	p value
Age >34 (vs ≤34 yrs)	-1.27 (-2.94, 0.41)	0.137	–	–
Female gender (vs male)	2.59 (0.83, 4.35)	0.004	–	–
Caucasian ethnicity (vs other)	-2.42 (-5.34, 0.50)	0.104	–	–
Tertiary education or greater (vs lesser)	-1.28 (-2.97, 0.41)	0.137	–	–
Physical HRQoL >50th (vs ≤50th centile)	-1.16 (-2.08, -0.24)	0.013	-1.08 (-1.69, -0.47)	0.001
Mental HRQoL >50th (vs ≤50th centile)	-2.08 (-2.98, -1.19)	<0.001	-1.24 (-1.82, -0.65)	<0.001
Opiate substitution therapy, current (vs none)	0.39 (-1.22, 1.99)	0.637	–	–
Injecting drug use, ever (vs never)	5.56 (3.78, 7.34)	<0.001	2.25 (1.08, 3.41)	<0.001
Injecting drug use, in last 6mo (vs none)	6.59 (4.89, 8.30)	<0.001	–	–
Injecting drug use, in last 1mo (vs none)	3.50 (2.39, 4.61)	<0.001	–	–
Sharing needles/equipment, in last 1mo (vs none)	1.40 (-0.27, 3.07)	0.100	–	–
Alcohol use in last month (vs none)	-1.36 (-2.46, -0.26)	0.016	–	–
Alcohol >2 drinks/day, last month (vs ≤2)	0.95 (-0.46, 2.36)	0.187	–	–
Major depression current (vs none)	3.17 (2.10, 4.23)	<0.001	1.36 (0.59, 2.14)	0.001
HIV co-infected (vs uninfected)	-4.79 (-6.40, -3.13)	<0.001	-3.31 (-4.40, -2.22)	<0.001
Symptomatic acute HCV (vs asymptomatic)	-1.85 (-3.76, 0.05)	0.057	–	–
Treatment (vs no treatment)	-2.69 (-4.50, -0.89)	0.003	n/a1	n/a1
SVR (vs no SVR)	-2.30 (-4.38, -0.28)	0.026	-1.29 (-2.41, -0.16)	0.025
Spontaneous clearance (vs persisting viraemia)	1.85 (-0.73, 3.76)	0.185	–	–
IFNL4 genotype CC (vs non-CC)	-1.34 (-3.09, 0.40)	0.130	–	–

¹Treatment and SVR co-linear; treatment removed from final model.

$\widehat{\text{a}}$ coeff, adjusted co-efficient.