Table 3. Clinical parameter changes after treatment and at follow-up.
POST vs BASELINE | FOLLOW-UP vs BASELINE | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Parameter | Within groups | Between groups | Within groups | Between groups | ||||||||
rtACS | Sham | rtACS | Sham | |||||||||
mean ±SEM | p | mean ±SEM | p | mean ±SEM | p | mean ±SEM | p | mean ±SEM | p | mean ±SEM | p | |
High Resolution Perimetry | ||||||||||||
Detection accuracy in whole visual field, % | 23.96 ±10.1 | <0.001 | 2.53 ±2.75 | 0.256 | 21.43 ±10.46 | 0.011 | 24.98 ±11.01 | 0.006 | 0.28 ±3.34 | 0.482 | 24.70 ±11.51 | 0.033 |
Detection accuracy in defective visual field sectors, % | 59.86 ±13.44 | <0.001 | 34.83 ±5.30 | <0.001 | 25.03 ±14.44 | 0.131 | 61.29 ±16.14 | <0.001 | 30.72 ±5.96 | <0.001 | 30.56 ±17.21 | 0.078 |
Detection accuracy within 5° visual field, % | 63.24 ±55.67 | 0.075 | 1.13 ±3.90 | 0.472 | 62.11 ±55.80 | 0.170 | 66.74 ±51.45 | 0.081 | -0.96 ±2.46 | 0.500 | 67.71 ±51.51 | 0.146 |
Fixation accuracy (%) | 12.20 ±8.62 | 0.015 | 5.66 ±3.55 | 0.016 | 6.54 ±9.32 | 0.427 | 30.48 ±19.77 | 0.076 | 6.08 ±2.91 | 0.013 | 24.40 ±19.98 | 0.390 |
False positive reactions in % | 33.75 ±9.97 | 0.003 | 22.73 ±18.10 | 0.237 | 11.01 ±20.67 | 0.076 | 50.18 ±12.92 | <0.001 | 46.70 ±22.74 | 0.034 | 3.49 ±26.15 | 0.134 |
RT whole visual field (ms) | 2.13 ±0.87 | 0.022 | 1.30 ±1.19 | 0.086 | 0.86 ±1.47 | 0.338 | 1.49 ±0.89 | 0.084 | 0.59 ±1.30 | 0.383 | 0.90 ±1.58 | 0.242 |
RT in defective visual field sectors (ms) | 2.03 ±0.96 | 0.063 | 1.48 ±1.04 | 0.075 | 0.55 ±1.42 | 0.452 | 1.61 ±0.87 | 0.086 | 2.22 ±1.62 | 0.127 | -0.60 ±1.84 | 0.485 |
RT within 5° visual field (ms) | 3.46 ±1.00 | 0.001 | 2.74 ±1.43 | 0.013 | 0.72 ±1.74 | 0.437 | 3.41 ±1.27 | 0.006 | 2.44 ±1.51 | 0.052 | 0.97 ±1.97 | 0.383 |
Static Perimetry | ||||||||||||
Foveal threshold (dB) | -1.72 ±4.03 | 0.367 | 0.05 ±5.80 | 0.297 | -1.77 ±7.06 | 0.402 | 1.13 ±3.00 | 0.368 | -7.52 ±4.22 | 0.174 | 8.65 ±5.18 | 0.151 |
Mean threshold (whole visual field, dB) | 22.38 ±10.67 | 0.003 | 3.72 ±5.00 | 0.272 | 18.65 ±11.78 | 0.063 | 34.97 ±18.52 | 0.001 | 2.14 ±4.59 | 0.486 | 32.83 ±19.08 | 0.010 |
Fixation accuracy in static perimetry, % | 0.93 ±3.36 | 0.373 | 2.82 ±2.62 | 0.129 | -1.89 ±4.26 | 0.206 | 10.69 ±10.19 | 0.197 | -4.00 ±3.62 | 0.205 | 14.70 ±10.81 | 0.192 |
Kinetic Perimetry | ||||||||||||
Mean eccentricity (°) | 11.62 ±6.27 | 0.035 | 6.40 ±5.13 | 0.063 | 5.22 ±8.10 | 0.406 | 2.51 ±5.45 | 0.426 | 4.47 ±4.37 | 0.159 | -1.96 ±6.99 | 0.285 |
Mean visual field size (square degree) | 27.27 ±16.44 | 0.036 | 20.47 ±15.89 | 0.040 | 6.80 ±22.90 | 0.385 | 11.23 ±11.86 | 0.413 | 9.06 ±6.90 | 0.184 | 2.17 ±13.72 | 0.29 |
Visual acuity | ||||||||||||
Uncorrected near vision | -0.014 ±0.016 | 0.267 | -0.082 ±0.020 | <0.001 | 0.068 ±0.026 | 0.012 | -0.066 ±0.017 | 0.001 | -0.068 ±0.025 | 0.002 | 0.003 ±0.029 | 0.370 |
Uncorrected far vision | -0.039 ±0.023 | 0.067 | -0.032 ±0.019 | 0.032 | -0.007 ±0.030 | 0.371 | -0.020 ±0.025 | 0.257 | -0.032 ±0.019 | 0.064 | 0.012 ±0.031 | 0.226 |
For cases with binocular lesions values for both eyes were averaged. Results are given as mean and standard error mean (SEM).