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Neonatal rat cardiomyocytes were exposed to recombinant HMGB1 (rHMGB1). (A) Effect of rHMGB1 on p-ERK1/2. (B) Cell viability was detected with MTT assay. (C) Cell proliferation detected with CCK8 assay. (D) Cell surface area in response to rHMGB1 in the absence/presence of anti-RAGE neutralizing antibody. Results are means ± SEM. n = 6 in each dose group in panel A-C, n = 50 cells in each group and *P <0.05 vs. 1st bar in panel D.
