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. 2016 Jul 1;27(13):2133–2144. doi: 10.1091/mbc.E15-07-0490

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© 2016 Loucks, Bialas, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — efhc-1 mutant alleles, localization of EFHC-1::GFP, and a reduction in lifespan in efhc-1 mutants. (A) Gene model for the Y49A10A.1 (efhc-1) gene in the nematode. Positions and size/nature of the two alleles examined in this study (gk424336 and tm6235). (B) Localization of EFHC-1::GFP to the four OLQ and the four CEP cilia of C. elegans. Basal body regions (BB) are indicated by orange ovals, cilia by green lines, and dendrites by gray lines. Scale bar, 5 μm. (C) Both efhc-1(gk424336) and efhc-1(tm6235) worms show significantly decreased lifespans compared with wild type (N2). (D) The reduced lifespan in efhc-1 mutants is similar to the lifespan of pcrg-1 mutants, as well as of double mutants, suggesting that the two genes work in the same genetic pathway to regulate lifespan. For number of animals and p values comparing differences between strains in lifespan experiments, see Supplemental Table S1.