. Author manuscript; available in PMC: 2017 Jul 1.

Published in final edited form as: Immunogenetics. 2016 May 3;68(6-7):391–400. doi: 10.1007/s00251-016-0914-1

Table 4.

Mediation Analysis Results for Top Asthma Susceptibility Associations in SAGE II.

Chr.	Gene	SNP	Proportion of SNP Effect Mediated by Obesity	95% CI	P-Value
10	PTCHD3	rs660498	0.04	−0.02 – 0.09	0.34
10	PTCHD3	rs2484180	0.04	−0.04 – 0.10	0.51
7	SEMA3E	rs17446324	0.02	−0.03 – 0.10	0.50
19	INSR	rs67731056	0.02	−0.05 – 0.06	0.85

¹Chr; Chromosome

²Proportion of the total effect of SNP genotype on asthma status that is mediated by obesity status; estimate of the proportion of the total SNP effect that is due to the indirect effect of SNP genotype on asthma status. Model allows for interaction between predictor (SNP) and mediator (obesity status).

³95% CI: 95% (Bootstrap) Confidence Intervals (n=1000)