Figure 1. Characterization of mice with a liver specific KO of CPT2.

(A) Western blot for CPT2 in liver of Cpt2^lox/lox and Cpt2^L−/− mice.

(B) mRNA for Cpt2 across different tissues (n=6).

(C) Oxidation of 1-¹⁴C-oleic acid and 1-¹⁴C-Lignoceric acid to ¹⁴CO₂ in liver slices of Cpt2^lox/lox and Cpt2^L−/− mice (n=5).

(D) Body weights of Cpt2^lox/lox and Cpt2^L−/− male and female mice fed a normal chow diet (males, n=14-23; females, n=8-12).

Data are expressed as mean ± SEM. *p<0.05; **p<0.01; ***p<0.001.