Table 2.

MicroRNAs consistently altered in the serum of prostate cancer patients and the related pathways consequently altered

		Trend	Putative targets	Pathway	References
Plasma	miR-141	Up	SHP	AR	[31,33,36]
	miR-375	Up	MYC, CCND2	Proliferation	[31,33,34,36,37]
	miR-221	Up	p27kip1	Cell cycle, AR	[29,33]
	miR-181a	Down	LEF1, BCL2	EMT, apoptosis	[31]
	miR-21	Up	p57kip2, PTEN	Proliferation	[33,50,51]

AR = androgen receptor; EMT = epithelial–mesenchymal transition.