Table 3.

Association of biomarkers with ischemic stroke

Parameter Cut off	Unadjusted HR (95% CI)	Model 1* HR (95% CI)	Model 2** HR (95% CI)
Copeptin
First quartile <3.9 pmol/L	Reference
Second quartile 3.9–6.6 pmol/L	0.8 (0.5–1.5)	0.7 (0.4–1.4)	0.8 (0.4 – 1.6)
Third quartile 6.7– 11.5 pmol/L	0.7 (0.7–2.1)	1.0 (0.6–1.9)	1.2 (0.6 – 2.1)
Fourth quartile >11.5 pmol/L	1.6 (0.9–2.8)	1.2 (0.7–2.2)	1.1 (0.6 – 2.2)
Mid Regional pro-Atrial Natriuretic Peptide
First quartile > 58.4 pmol/L	Reference
Second quartile 58.4–91.1 pmol/L	1.5 (0.9–2.8)	1.5 (0.8–2.9)	1.3 (0.7 – 2.5)
Third quartile 91.2–144.8 pmol/L	1.8 (0.9–3.1)	1.6 (0.8–3.0)	1.6 (0.8 – 3.1)
Fourth quartile >144.8 pmol/L	4.5 (2.6–7.8)	3.9 (1.9–7.6)	3.5 (1.6 – 7.5)
Procalcitonin
First quartile < 0.02 ug/L	Reference
Second quartile 0.02– 0.03 ug/L	1.9 (1.1–3.4)	1.7 (0.9–3.2)	1.7 (0.9 – 3.4)
Third quartile 0.031–0.05 ug/L	1.7 (0.9–3.2)	1.6 (0.8–2.9)	1.8 (0.9 – 3.5)
Fourth quartile >0.05 ug/L	2.4 (1.3–4.3)	2.1 (1.1–3.9)	1.9 (1.0 – 3.8)

^*Model 1; adjusted for demographics (i.e. age, sex, race-ethnicity, education)

^**Model 2; adjusted for age, sex, race-ethnicity, education, physical activity, smoking-status, diabetes mellitus, hypertension, cardiac disease, low density lipoprotein, high density lipoprotein, estimated glomerular-filtration-rate