Table 2.

Risk factors associated with LTFU

Variable	Overall: number LTFU/Number of patients	During TB treatment		After TB treatment		Before ART initiation		After ART initiation		Overall (at 24 months)
		aHR (95%CI)	p-value	aHR (95%CI)	p-value	aHR (95%CI)	p-value	aHR (95%CI)	p-value	aHR (95%CI)	p-value
a Trial arm
Late integrated arm	36/215	1.8 (0.9–3.5)	0.080	0.8 (0.4–1.9)	0.695	1.6 (0.6–4)	0.348	0.6 (0.3–1.3)	0.218	1.4 (0.8–2.3)	0.222
Sequential arm	34/213	1.8 (0.9–3.5)	0.080	0.8 (0.4–1.9)	0.662	1.2 (0.5–3.2)	0.659	0.3† (0.1–0.8)	0.024	1.4 (0.8–2.3)	0.230
Age (per 5 year increase)		0.8† (0.6–0.9)	0.004	0.8 (0.7–1.0)	0.098	0.7† (0.6–0.9)	0.003	0.9 (0.8–1.1)	0.456	0.8† (0.7–0.9)	0.002
b Gender
Male	57/319	1.8† (1.03–3.1)	0.038	2.4† (1.1–5.0)	0.024	1.9† (1.1–3.3)	0.032	1.8 (0.9–3.8)	0.098	1.9† (1.2–3.0)	0.004
c CD4+ cell count (cells/mm3)
<200	51/408	0.6 (0.3–1.2)	0.158	0.5 (0.2–1.4)	0.194	0.8 (0.4–1.7)	0.576	0.5 (0.2–1.4)	0.211	0.6† (0.3–0.99)	0.049
200–350	28/160	0.9 (0.4–1.8)	0.700	0.6 (0.2–1.6)	0.269	0.9 (0.4–2.0)	0.800	0.9 (0.3–2.5)	0.774	0.7 (0.4–1.3)	0.314
d Past history of TB
Yes	29/214	1.2 (0.7–2.1)	0.534	0.6 (0.3–1.4)	0.264	1.2 (0.7–2.2)	0.437	0.5 (0.2–1.2)	0.116	1.0 (0.6–1.5)	0.867
e WHO stage
Stage 4	4/38	0.3 (0–1.9)	0.189	1.4 (0.4–4.8)	0.557	No estimate		1.9 (0.7–5.6)	0.230	0.7 (0.2–1.8)	0.433
f Employment status
Employed	55/369	1.7 (0.99–3.0)	0.061	0.3† (0.1–0.6)	0.002	1.4 (0.8–2.4)	0.227	0.6 (0.3–1.2)	0.135	0.9 (0.6–1.4)	0.710

aHR: Adjusted hazard ratio, LTFU: lost to follow-up, TB: tuberculosis, ART: antiretroviral therapy, CI: Confidence Interval

Reference categories for each predictor variable:

^aEarly integrated arm (26/214),

^bFemale (39/323),

^cCD4 cell count>350 cells/mm³ (17/74),

^dNo past history of TB (67/428),

^eWHO stage 3 (92/604),

^fUnemployed (41/273)

^†Statistically significant at a 5% level of significance