Table 1.
Sociodemographic and clinical characteristics of 79 participants in the Detroit Neighborhood Health Study.
| Characteristic | Overall | Annual household income | |
|---|---|---|---|
| <$35K N=57 |
≥$35K N=22 |
||
| Age in years, median (IQR) | 45 (35, 56) | 44 (36, 54) | 50 (35, 56) |
| Gender, N (%) | |||
| Female | 50 (63.3) | 36 (63.2) | 14 (63.6) |
| Male | 29 (36.7) | 21 (36.8) | 8 (36.4) |
| Race, N (%) | |||
| Black | 63 (79.7) | 48 (84.2) | 15 (68.2) |
| Non-black | 16 (20.2) | 9 (15.8) | 7 (31.8) |
| Education, N (%) | |||
| ≤High school | 38 (48.1) | 32 (56.1) | 6 (27.3) |
| >High school | 41 (51.9) | 25 (43.9) | 16 (72.7) |
| Annual Household Income, median (IQR) | $20,000 ($10,000 – $42,500) | -- | -- |
| Medication usea, N (%) | |||
| Yes | 32 (42.1) | 24 (44.4) | 8 (36.4) |
| No | 44 (57.9) | 30 (55.6) | 14 (63.6) |
| Lifetime history of mental health condition,b N (%) | |||
| Yes | 41 (51.9) | 32 (56.1) | 9 (40.9) |
| No | 38 (48.1) | 25 (43.9) | 13 (59.1) |
| Cigarette use in lifetime, N (%) | |||
| Yes | 48 (60.8) | 40 (70.2) | 8 (36.4) |
| No | 31 (39.2) | 17 (29.8) | 14 (63.6) |
| CMV serostatus, N (%) | |||
| Seropositive | 61 (77.2) | 48 (84.2) | 13 (59.1) |
| Seronegative | 18 (22.8) | 9 (15.8) | 9 (40.9) |
| CMV IgG antibody level, median (IQR) | 3.64 (1.29, 6.57) | 4.46 (2.33, 7.20) | 2.31 (0.71, 4.37) |
| CD4 E:N ratio, median (IQR) | 0.05 (0.00, 0.20) | 0.07 (0.00, 0.21) | 0.00 (0.00, 0.10) |
| CD8 E:N ratio, median (IQR) | 1.25 (0.37, 3.72) | 1.63 (0.48, 4.20) | 0.52 (0.16, 1.81) |
| CD4:CD8 ratio, median (IQR) | 2.18 (1.65, 2.75) | 2.12 (1.61, 2.66) | 2.38 (1.75, 3.14) |
| PBMC count (Millions of cells), median (IQR) | 21 (18, 27) | 22 (18, 28) | 20 (17, 24) |
Abbreviations: CMV, cytomegalovirus; E:N ratio, ratio of end-stage non-proliferative effector cells (E; CCR7−CD45RA+CD27−CD28− or TEMRA) to naïve T-cells (N; CCR7+CD45RA+CD27+CD28+)
a
Medications included antimicrobial agents, cardiovascular-renal drugs, central nervous system medications, metabolic and nutrient agents, hormones and agents affecting hormonal mechanisms, immunologic agents, oncolytics, and drugs used for relief of pain.
b
Mental health conditions included generalized anxiety disorder, major depressive disorder, and post-traumatic stress disorder.