Table 2.

Age adjusted associations between participant characteristics and the distribution of T-cell phenotypes among 79 participants in the Detroit Neighborhood Health Study.

		β (95% CI)
	Log CD4 E:N Ratio	Log CD8 E:N Ratio	Log CD4:CD8 Ratio
Each 10-year increase in age	0.51 (0.08, 0.93)**	0.53 (0.29, 0.77)**	−0.00 (−0.07, 0.06)
Gender
Female	−0.13 (−1.55, 1.28)	−0.91 (−1.69, −0.13)**	0.15 (−0.05, 0.36)
Male	REF	REF	REF
Race
Black	1.02 (−0.62, 2.66)	0.23 (−0.71, 1.17)	−0.10 (−0.35, 0.14)
Non-black	REF	REF	REF
Education
≤High school	−0.16 (−1.48, 1.16)	0.31 (−0.44, 1.06)	−0.00 (−0.20, 0.19)
>High school	REF	REF	REF
Each $10K decrease in annual household income	0.37 (0.08, 0.66)**	0.15 (−0.02, 0.32)*	−0.03 (−0.07, 0.02)
Medication usea
Yes	−0.47 (−1.92, 0.98)	−0.36 (−1.21, 0.49)	0.04 (−0.17, 0.25)
No	REF	REF	REF
Lifetime history of mental health conditionb
Yes	−0.17 (−1.50, 1.15)	−0.18 (−0.93, 0.57)	−0.05 (−0.24, 0.15)
No	REF	REF	REF
Cigarette use in lifetime
Yes	0.69 (−0.66, 2.03)	0.29 (−0.48, 1.06)	−0.08 (−0.28, 0.12)
No	REF	REF	REF
CMV serostatus
Seropositive	3.80 (2.46, 5.14)**	1.15 (0.28, 2.02)**	−0.13 (−0.36, 0.11)
Seronegative	REF	REF	REF
Each 1 unit increase in CMV IgG antibody level	0.49 (0.31, 0.67)**	0.18 (0.07, 0.29)**	−0.01 (−0.04, 0.02)

Abbreviations: CMV, cytomegalovirus; E:N ratio, ratio of end-stage non-proliferative effector cells (E; CCR7−CD45RA+CD27−CD28− or TEMRA) to naïve T-cells (N; CCR7+CD45RA+CD27+CD28+)

^*p value <0.10

^**p value <0.05

^aMedications included antimicrobial agents, cardiovascular-renal drugs, central nervous system medications, metabolic and nutrient agents, hormones and agents affecting hormonal mechanisms, immunologic agents, oncolytics, and drugs used for relief of pain.

^bMental health conditions included generalized anxiety disorder, major depressive disorder, and post-traumatic stress disorder.