Table 4. Paired t-test and effect size analyses on absolute surface errors for landmarks with healthy anatomy and WM lesions with MaCRUISE⁺.

Landmarks			Rater A		Rater B		Rater C

			P value	Cohen's d	P value	Cohen's d	P value	Cohen's d
Healthy Anatomy		Outer Surface	<0.001	0.186	<0.001	0.124
		Inner Surface	<0.001	0.177	<0.001	0.098

		Outer Surface	<0.001	0.226	0.037	0.028
		Inner Surface	<0.001	0.057	0.002	0.065

		Outer Surface	<0.001	0.040	<0.001	0.170
		Inner Surface	0.330	0.006	0.145	0.063

Near WM Lesions	MaCRUISE⁺ vs.FreeSurfer	Outer Surface	0.022	0.149	0.011	0.162	<0.001	0.315
	MaCRUISE⁺ vs.FreeSurfer	Inner Surface	<0.001	0.417	0.024	0.191	<0.001	0.594

	MaCRUISE⁺ vs. Corrected FreeSurfer^*	Outer Surface	0.870	0.010	0.249	0.059	<0.001	0.213
	MaCRUISE⁺ vs. Corrected FreeSurfer^*	Inner Surface	<0.001	0.355	0.147	0.128	<0.001	0.526

		Outer Surface	<0.001	0.170	<0.001	0.137	0.003	0.103
		Inner Surface	0.013	0.110	0.005	0.115	0.002	0.121

FreeSurfer after correction with the WM lesion masks generated by Lesion-TOADS.

Please see Table 2 for a description of effect size with Cohen's d score.

Table 4. Paired t-test and effect size analyses on absolute surface errors for landmarks with healthy anatomy and WM lesions with MaCRUISE+.