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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: J Clin Psychopharmacol. 2016 Aug;36(4):347–354. doi: 10.1097/JCP.0000000000000511

Table 4.

Amphetamine pharmacokinetic parameters following intravenous methamphetamine (MA; 15 mg and 30 mg) during treatment with ibudilast 20 mg twice daily (BID), 50 mg BID, or placebo BID in MA dependent volunteers (N=11).

Amphetamine
Pharmacokinetic
Parameter		 Methamphetamine
dose (mg)		 Group Mean (Standard Error)
Placebo Ibudilast
20 mg BID		 Ibudilast
50 mg BID
Cmax (ng/ml) 15 1.80 (0.28) 2.26 (0.39) 2.59 (0.73)
30 3.93 (0.51) 4.42 (0.72) 4.14 (0.59)
Tmax (hr) 15 9.83 (1.45) 7.80 (1.57) 8.20 (1.66)
30 10.4 (1.2) 12.0 (0.0) 12.0 (0.0)
AUC∞ (ng hr/ml) 15 89.8 (25.6) 116 (31) 65.8 (10.7)
30 167 (27) 221 (32) 203 (42)